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A Viação Expresso Santa Marta é uma empresa de ônibus fundada em 1965, em Goiânia, pela Família Caetano. No início de sua operação, a empresa tinha linhas que percorriam diversas cidades do interior do estado de Goiás. Já na década de 1980, com a expansão da companhia, passou a oferecer outros tipos de serviços nas áreas de turismo e eventos.
Atualmente, entre os trechos oferecidos pela Viação Expresso Santa Marta, é possível comprar passagens de ônibus online para as cidades de Goiânia, Barra do Garças, Anápolis, entre outros destinos.